Increased Infiltration of Extra-Cardiac Cells in Myxomatous Valve Disease
نویسندگان
چکیده
منابع مشابه
Increased Infiltration of Extra-Cardiac Cells in Myxomatous Valve Disease
Mutations in the actin-binding gene Filamin-A have been linked to non-syndromic myxomatous valvular dystrophy and associated mitral valve prolapse. Previous studies by our group traced the adult valve defects back to developmental errors in valve interstitial cell-mediated extracellular matrix remodeling during fetal valve gestation. Mice deficient in Filamin-A exhibit enlarged mitral leaflets ...
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INTRODUCTION Myxomatous mitral valve disease (MMVD) is the single most common acquired cardiac disease of dogs and is a disease of significant veterinary importance. It also bears close similarities to mitral valve prolapse in humans and therefore is a disease of emerging comparative interest. We have previously mapped the structure of collagen fibrils in valve leaflets using synchrotron X-rays...
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When discussing myxomatous valve disease in dogs, one has in mind atrioventricular valves, in particular the mitral valve, which is affected the most commonly and followed by the tricuspid, aortic valve and pulmonic valve, the last being seldom degenerated. Myxomatous mitral valve disease (MVD) is the most common cause of heart failure in dogs (1). In literature it can be found under various na...
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متن کاملDevelopmental basis for filamin-A-associated myxomatous mitral valve disease.
AIMS We hypothesized that the structure and function of the mature valves is largely dependent upon how these tissues are built during development, and defects in how the valves are built can lead to the pathological progression of a disease phenotype. Thus, we sought to uncover potential developmental origins and mechanistic underpinnings causal to myxomatous mitral valve disease. We focus on ...
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ژورنال
عنوان ژورنال: Journal of Cardiovascular Development and Disease
سال: 2015
ISSN: 2308-3425
DOI: 10.3390/jcdd2030200